As a Research Ethics Review Board (RERB), we are more than just another IRB. While the scope of IRB review is defined by regulation, advances in science and technology raise important issues of trust, rights, and welfare on which regulations are silent. These issues include the implications of research with Big Data, Artificial Intelligence and Machine Learning for science and healthcare delivery, the proper use of genetic data, and the obligation to make research opportunities accessible to all. For these and other areas, as an RERB, we acknowledge unanswered ethical questions in ways that promote discussion and give voice to the perspectives of research participants. We want to assure compliance AND build trust in research as a public good.